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Revisiting the global workspace orchestrating the hierarchical organization of the human brain

MPG-Autoren
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Deco,  Gustavo
Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain;
Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
School of Psychological Sciences, Monash University, Melbourne, Australia;

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Zitation

Deco, G., Vidaurre, D., & Kringelbach, M. L. (2021). Revisiting the global workspace orchestrating the hierarchical organization of the human brain. Nature Human Behaviour, 5(4), 497-511. doi:10.1038/s41562-020-01003-6.


Zitierlink: https://hdl.handle.net/21.11116/0000-0008-104C-1
Zusammenfassung
A central challenge in neuroscience is how the brain organizes the information necessary to orchestrate behaviour. Arguably, this whole-brain orchestration is carried out by a core subset of integrative brain regions, a 'global workspace', but its constitutive regions remain unclear. We quantified the global workspace as the common regions across seven tasks as well as rest, in a common 'functional rich club'. To identify this functional rich club, we determined the information flow between brain regions by means of a normalized directed transfer entropy framework applied to multimodal neuroimaging data from 1,003 healthy participants and validated in participants with retest data. This revealed a set of regions orchestrating information from perceptual, long-term memory, evaluative and attentional systems. We confirmed the causal significance and robustness of our results by systematically lesioning a generative whole-brain model. Overall, this framework describes a complex choreography of the functional hierarchical organization of the human brain.