The “small” conductance chloride channel in the luminal membrane of the rectal 
gland of the dogfish (Squalus acanthias)

Gögelein, Heinz; Schlatter, Eberhard; Greger, Rainer

doi:10.1007/BF00584758

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The “small” conductance chloride channel in the luminal membrane of the rectal gland of the dogfish (Squalus acanthias)

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Gögelein, Heinz
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Mount Desert Island Biological Laboratory, 04672, Salsbury Cove, ME, USA;

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Citation

Gögelein, H., Schlatter, E., & Greger, R. (1987). The “small” conductance chloride channel in the luminal membrane of the rectal gland of the dogfish (Squalus acanthias). Pflügers Archiv: European Journal of Physiology, 409, 122-125. doi:10.1007/BF00584758.

Cite as: https://hdl.handle.net/21.11116/0000-0008-1A78-5

Abstract

Besides the “larger” Cl⁻ channel with a single channel conductance of about 45 pS, a “small” channel was observed in the luminal membrane of the dogfish rectal gland [9]. In cell excised (inside out) patches with NaCl solution on both sides, the latter channel had a single channel conductance of 11±1 pS (n=21), and its current-voltage relationship was linear in the voltage range+90 to −90 mV. The open state probability increased moderately with negative clamp potentials. Ionic replacement studies revealed a high selectivity of Cl⁻ over gluconate, sulfate, and iodide, whereas bromide was permeable to some extent. Also the channel is impermeable for Na⁺. The Cl⁻ channel blocker 5-nitro-2-(3-phenylpropylamino)-benzoate did not affect this “small” conductance Cl⁻ channel. It can be concluded that the luminal membrane of stimulated rectal gland cells possesses two types of Cl⁻ channels, which differ markedly in their characteristics.