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Journal Article

Single K+ channels in the apical membrane of amphibian peritoneum

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Grygorczyk,  Ryszard
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Marek,  Simon
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Grygorczyk, R., & Marek, S. (1986). Single K+ channels in the apical membrane of amphibian peritoneum. Biochimica et Biophysica Acta-Biomembranes, 861, 385-388. doi:10.1016/0005-2736(86)90444-X.


Cite as: http://hdl.handle.net/21.11116/0000-0008-1328-6
Abstract
Application of the patch-clamp technique to the apical membrane of amphibian peritoneum revealed a K+ permeability governed by voltage-dependent, K+-permeable channels (PK/PNa = 3.5) that are reversibly blocked by 20 mmol/l internally applied tetraethylammonium. The channels show discrete and multiple conductance levels with elementary conductance of about 22 pS (in 120 mmol/l KCl solution on both sides of the membrane). The channels' behaviour is consistent with an aggregation of channel-forming subunits into clusters with cooperative gating mechanism.