Cell-type specific innervation of cortical pyramidal cells at their apical 
dendrites

Karimi, A.; Odenthal, J.; Drawitsch, F.; Boergens, K. M.; Helmstaedter, Moritz

doi:10.7554/eLife.46876

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Cell-type specific innervation of cortical pyramidal cells at their apical dendrites

MPS-Authors

Karimi, A.
Connectomics Department, Max Planck Institute for Brain Research, Max Planck Society;

Odenthal, J.
Connectomics Department, Max Planck Institute for Brain Research, Max Planck Society;

Drawitsch, F.
Connectomics Department, Max Planck Institute for Brain Research, Max Planck Society;

Boergens, K. M.
Connectomics Department, Max Planck Institute for Brain Research, Max Planck Society;

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Helmstaedter, Moritz
Connectomics Department, Max Planck Institute for Brain Research, Max Planck Society;

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http://www.ncbi.nlm.nih.gov/pubmed/32108571
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Citation

Karimi, A., Odenthal, J., Drawitsch, F., Boergens, K. M., & Helmstaedter, M. (2020). Cell-type specific innervation of cortical pyramidal cells at their apical dendrites. eLife, 9: e46876. doi:10.7554/eLife.46876.

Cite as: https://hdl.handle.net/21.11116/0000-0008-17A5-4

Abstract

We investigated the synaptic innervation of apical dendrites of cortical pyramidal cells in a region between layers (L) 1 and 2 using 3-D electron microscopy applied to four cortical regions in mouse. We found the relative inhibitory input at the apical dendrite’s main bifurcation to be more than 2-fold larger for L2 than L3 and L5 thick-tufted pyramidal cells. Towards the distal tuft dendrites in upper L1, the relative inhibitory input was at least about 2-fold larger for L5 pyramidal cells than for all others. Only L3 pyramidal cells showed homogeneous inhibitory input fraction. The inhibitory-to-excitatory synaptic ratio is thus specific for the types of pyramidal cells. Inhibitory axons preferentially innervated either L2 or L3/5 apical dendrites, but not both. These findings describe connectomic principles for the control of pyramidal cells at their apical dendrites and support differential computational properties of L2, L3 and subtypes of L5 pyramidal cells in cortex.