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Journal Article

Does sphingomyelin inhibit the erythrocyte anion transport system?

MPS-Authors
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Scheuring,  Uwe
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Haase,  Winfried
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Schubert,  Dieter
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Scheuring, U., Haase, W., & Schubert, D. (1988). Does sphingomyelin inhibit the erythrocyte anion transport system? FEBS Letters, 231(1), 232-236. doi:10.1016/0014-5793(88)80738-5.


Cite as: https://hdl.handle.net/21.11116/0000-0008-1A61-E
Abstract
The anion transport protein of the human erythrocyte membrane, band 3, was incorporated into unilamellar sphingomyelin vesicles. The vesicles showed a rapid sulfate efflux which could be inhibited by specific inhibitors of the erythrocyte anion transport system. All band 3 molecules contributing to the inhibitor-sensitive flux component were arranged 'right-side-out'. The turnover number of the transport protein for sulfate transport was virtually identical to that in phosphatidylcholine bilayers and around 6 times larger than in human erythrocyte membranes. Thus, in contrast to other claims, sphingomyelin does not inhibit the erythrocyte anion transport system.