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Journal Article

Sugar transport by renal plasma membrane vesicles. Characterization of the systems in the brush-border microvilli and basal-lateral plasma membranes

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Kinne,  Rolf
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Laboratory of Membrane Biology, University of Alabama, 35294, Birmingham, Alabama;

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Murer,  Heini
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Laboratory of Membrane Biology, University of Alabama, 35294, Birmingham, Alabama;

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Kinne-Saffran,  Evamaria
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Laboratory of Membrane Biology, University of Alabama, 35294, Birmingham, Alabama;

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Thees,  M.
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Laboratory of Membrane Biology, University of Alabama, 35294, Birmingham, Alabama;

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Sachs,  George
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Kinne, R., Murer, H., Kinne-Saffran, E., Thees, M., & Sachs, G. (1975). Sugar transport by renal plasma membrane vesicles. Characterization of the systems in the brush-border microvilli and basal-lateral plasma membranes. Journal of Membrane Biology, 21, 375-395. doi:10.1007/BF01941077.


Cite as: https://hdl.handle.net/21.11116/0000-0009-BE61-4
Abstract
Uptake studies ofD- andL-glucose were performed on vesicles derived from brush-border and basal-lateral membranes. The uptake of the sugars into the vesicles was osmotically sensitive and independent of glucose metabolism. In brush-border vesiclesD-glucose but notL-glucose transport was Na+-dependent, was inhibited by phlorizin, and showed a transitory vesicle/medium ratio >1, in the presence of an initial Na+ gradient. Basal-lateral membranes take upD-glucose faster thanL-glucose, but theD-glucose uptake is significantly less sensitive to sodium removal and only moderately inhibited by phlorizin as compared to the brush-border fraction.