How to make a better T cell: in vivo CRISPR screens have some answers

Villa, Matteo; Stanczak, Michal A; Pearce, Erika Laine

doi:10.1016/j.cell.2021.02.003

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How to make a better T cell: in vivo CRISPR screens have some answers

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Villa, Matteo
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Stanczak, Michal A
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Pearce, Erika Laine
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Villa, M., Stanczak, M. A., & Pearce, E. L. (2021). How to make a better T cell: in vivo CRISPR screens have some answers. Cell, 184, 1135-1136. doi:10.1016/j.cell.2021.02.003.

Cite as: https://hdl.handle.net/21.11116/0000-0008-20E0-6

Abstract

Understanding what regulates CD8⁺ T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8⁺ T cell immunity to engineer a more efficacious response against cancer and infections.