Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease

Solopchuk, O; Sebti, M; Bouvy, C; Benoit, C-E; Warlop, T; Jeanjean, A; Zénon, A

doi:10.1038/s41598-018-30128-y

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

https://www.nature.com/articles/s41598-018-30128-y.pdf
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Solopchuk, O., Sebti, M., Bouvy, C., Benoit, C.-E., Warlop, T., Jeanjean, A., et al. (2018). Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease. Scientific Reports, 8(1): 12381, pp. 1-7. doi:10.1038/s41598-018-30128-y.

Cite as: https://hdl.handle.net/21.11116/0000-0008-280F-C

Abstract

Fatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in Parkinson’s disease (PD). Earlier studies have examined the role of dopamine and serotonin in pathogenesis of fatigue, but the plausible role of noradrenalin (NA) remains underexplored. We investigated the relationship between fatigue in Parkinsonian patients and the extent of degeneration of Locus Coeruleus (LC), the main source of NA in the brain. We quantified LC and Substantia Nigra (SN) atrophy using neuromelanin-sensitive imaging, analyzed with a novel, fully automated algorithm. We also assessed patients’ fatigue, depression, sleep disturbance and vigilance. We found that LC degeneration correlated with the levels of depression and vigilance but not with fatigue, while fatigue correlated weakly with atrophy of SN. These results indicate that LC degeneration in Parkinson’s disease is unlikely to cause fatigue, but may be involved in mood and vigilance alterations.