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A self-organized synthetic morphogenic liposome responds with shape changes to local light cues

MPS-Authors
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Gavriljuk,  Konstantin
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Scocozza,  Bruno
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons238219

Ghasemalizadeh,  Farid
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Seidel,  Hans
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons238223

Nandan,  Akhilesh P.
Lise Meitner Group Cellular Computations and Learning, Center of Advanced European Studies and Research (caesar), Max Planck Society;
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

Campos-Medina,  Manuel
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Schmick,  Malte
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Koseska,  Aneta
Lise Meitner Group Cellular Computations and Learning, Center of Advanced European Studies and Research (caesar), Max Planck Society;
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons98677

Bastiaens,  Philippe I. H.
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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s41467-021-21679-2.pdf
(Publisher version), 13MB

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Citation

Gavriljuk, K., Scocozza, B., Ghasemalizadeh, F., Seidel, H., Nandan, A. P., Campos-Medina, M., et al. (2021). A self-organized synthetic morphogenic liposome responds with shape changes to local light cues. Nature Communications, 12: 1548. doi:10.1038/s41467-021-21679-2.


Cite as: http://hdl.handle.net/21.11116/0000-0008-28C5-D
Abstract
Reconstituting artificial proto-cells capable of transducing extracellular signals into cytoskeletal changes can reveal fundamental principles of how non-equilibrium phenomena in cellular signal transduction affect morphogenesis. Here, we generated a Synthetic Morphogenic Membrane System (SynMMS) by encapsulating a dynamic microtubule (MT) aster and a light-inducible signaling system driven by GTP/ATP chemical potential into cell-sized liposomes. Responding to light cues in analogy to morphogens, this biomimetic design embodies basic principles of localized Rho-GTPase signal transduction that generate an intracellular MT-regulator signaling gradient. Light-induced signaling promotes membrane-deforming growth of MT-filaments by dynamically elevating the membrane-proximal tubulin concentration. The resulting membrane deformations enable recursive coupling of the MT-aster with the signaling system, which generates global self-organized morphologies that reorganize towards local external cues in dependence on prior shape. SynMMS thereby signifies a step towards bio-inspired engineering of self-organized cellular morphogenesis.