Aptamer-based proximity labeling guides covalent RNA modification

Englert, Daniel; Matveeva, Regina; Sunbul, Murat; Wombacher, Richard; Jäschke, Andres

doi:10.1039/D1CC00786F

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Aptamer-based proximity labeling guides covalent RNA modification

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Wombacher, Richard
Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Englert, D., Matveeva, R., Sunbul, M., Wombacher, R., & Jäschke, A. (2021). Aptamer-based proximity labeling guides covalent RNA modification. Chemical Communications, 57, 3480-3483. doi:10.1039/D1CC00786F.

Cite as: https://hdl.handle.net/21.11116/0000-0008-28F8-4

Abstract

We describe the development of a proximity-induced bio-orthogonal inverse electron demand Diels–Alder reaction that exploits the high-affinity interaction between a dienophile-modified RhoBAST aptamer and its tetramethyl rhodamine methyltetrazine substrate. We applied this concept for covalent RNA labeling in proof-of-principle experiments.