Biogenesis of spliceosomal small nuclear ribonucleoproteins

Fischer, U.; Englbrecht, C.; Chari, A.

doi:10.1002/wrna.87

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Biogenesis of spliceosomal small nuclear ribonucleoproteins

MPS-Authors

/persons/resource/persons133053

Chari, A.
Research Group of Structural Biochemistry and Mechanisms, MPI for Biophysical Chemistry, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Fischer, U., Englbrecht, C., & Chari, A. (2011). Biogenesis of spliceosomal small nuclear ribonucleoproteins. Wiley Interdisciplinary Reviews: RNA, 2(5), 718-731. doi:10.1002/wrna.87.

引用: https://hdl.handle.net/21.11116/0000-0008-2A9C-A

要旨

Virtually, all eukaryotic mRNAs are synthesized as precursor molecules that need to be extensively processed in order to serve as a blueprint for proteins. The three most prevalent processing steps are the capping reaction at the 5′‐end, the removal of intervening sequences by splicing, and the formation of poly (A)‐tails at the 3′‐end of the message by polyadenylation. A large number of proteins and small nuclear ribonucleoprotein complexes (snRNPs) interact with the mRNA and enable the different maturation steps. This chapter focuses on the biogenesis of snRNPs, the major components of the pre‐mRNA splicing machinery (spliceosome). A large body of evidence has revealed an intricate and segmented pathway for the formation of snRNPs that involves nucleo‐cytoplasmic transport events and elaborates assembly strategies. We summarize the knowledge about the different steps with an emphasis on trans‐acting factors of snRNP maturation of higher eukaryotes. WIREs RNA 2011 2 718–731 DOI: 10.1002/wrna.87