DNA methylation predicts age and provides insight into exceptional longevity of 
bats

Wilkinson, Gerald S.; Adams, Danielle M.; Haghani, Amin; Lu, Ake T.; Zoller, Joseph; Breeze, Charles E.; Arnold, Bryan D.; Ball, Hope C.; Carter, Gerald G.; Cooper, Lisa Noelle; Dechmann, Dina K. N.; Devanna, Paolo; Fasel, Nicolas J.; Galazyuk, Alexander V.; Günther, Linus; Hurme, Edward; Jones, Gareth; Knörnschild, Mirjam; Lattenkamp, Ella Z.; Li, Caesar Z.; Mayer, Frieder; Reinhardt, Josephine A.; Medellin, Rodrigo A.; Nagy, Martina; Pope, Brian; Power, Megan L.; Ransome, Roger D.; Teeling, Emma C.; Vernes, Sonja C.; Zamora-Mejías, Daniel; Zhang, Joshua; Faure, Paul A.; Greville, Lucas J.; Herrera M. , L. Gerardo; Flores-Martínez,  José J.; Horvath, Steve

doi:10.1038/s41467-021-21900-2

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学術論文

DNA methylation predicts age and provides insight into exceptional longevity of bats

MPS-Authors

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Devanna, Paolo
Neurogenetics of Vocal Communication Group, MPI for Psycholinguistics, Max Planck Society;

Lattenkamp, Ella Z.
Neurogenetics of Vocal Communication Group, MPI for Psycholinguistics, Max Planck Society;
Ludwig Maximilians University Munich;

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Vernes, Sonja C.
Neurogenetics of Vocal Communication Group, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;
The University of St Andrews;

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Wilkinson_etal_2021_DNA methylation predicts....pdf
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Wilkinson_et_al-2021suppl-Nature_Communications.pdf
(付録資料), 4MB

引用

Wilkinson, G. S., Adams, D. M., Haghani, A., Lu, A. T., Zoller, J., Breeze, C. E., Arnold, B. D., Ball, H. C., Carter, G. G., Cooper, L. N., Dechmann, D. K. N., Devanna, P., Fasel, N. J., Galazyuk, A. V., Günther, L., Hurme, E., Jones, G., Knörnschild, M., Lattenkamp, E. Z., Li, C. Z., Mayer, F., Reinhardt, J. A., Medellin, R. A., Nagy, M., Pope, B., Power, M. L., Ransome, R. D., Teeling, E. C., Vernes, S. C., Zamora-Mejías, D., Zhang, J., Faure, P. A., Greville, L. J., Herrera M., L. G., Flores-Martínez, J. J., & Horvath, S. (2021). DNA methylation predicts age and provides insight into exceptional longevity of bats. Nature Communications, 12:. doi:10.1038/s41467-021-21900-2.

引用: https://hdl.handle.net/21.11116/0000-0008-2C59-4

要旨

Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.