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Molecular cloning of substance P receptor cDNA from guinea-pig uterus

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Gorbulev,  Valentin
Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Akhundova,  Aida
Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Luzius,  Heike
Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Fahrenholz,  Falk
Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Gorbulev, V., Akhundova, A., Luzius, H., & Fahrenholz, F. (1992). Molecular cloning of substance P receptor cDNA from guinea-pig uterus. Biochimica et Biophysica Acta-Gene Structure and Expression, 1131(1), 99-102. doi:10.1016/0167-4781(92)90105-9.


Cite as: https://hdl.handle.net/21.11116/0000-0008-32AF-B
Abstract
A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative ligand affinity in the order: SP ⪢ neurokinin A > neurokinin B.