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Journal Article

Mixing “good and bad” annoys neutrophils

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Trompouki,  Eirini
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://ashpublications.org/blood/article/137/10/1272/475435/Mixing-good-and-bad-annoys-neutrophils
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Citation

Trompouki, E. (2021). Mixing “good and bad” annoys neutrophils. Blood, 137, 1272-1274. doi:10.1182/blood.2020009854.


Cite as: https://hdl.handle.net/21.11116/0000-0008-312D-F
Abstract
In this issue of Blood, Schürch et al show that signal recognition particle 54 (SRP54) mutations found in patients with congenital neutropenia act in a dominant-negative manner on the functionality of the wild-type SRP54, leading to neutropenia because of impaired splicing of the transcription factor X-box binding protein 1 (XBP1).