Structure-function studies on gastrointestinal hormones: I. Synthesis of 
secretin analogs and their biological and immunological properties

Moroder, Luis; Jaeger, Ernst; Drees, Fritz; Gemeiner, Manfred; Knof, Siegward; Stelzel, Hans-Peter; Thamm, Paul; Bataille, Dominique; Domschke, Sigurd; Schlegel, Werner; Schulz, Irene; Wünsch, Erich

doi:10.1016/0045-2068(80)90031-0

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Structure-function studies on gastrointestinal hormones: I. Synthesis of secretin analogs and their biological and immunological properties

MPS-Authors

/persons/resource/persons256387

Schulz, Irene
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Moroder, L., Jaeger, E., Drees, F., Gemeiner, M., Knof, S., Stelzel, H.-P., et al. (1980). Structure-function studies on gastrointestinal hormones: I. Synthesis of secretin analogs and their biological and immunological properties. Bioorganic Chemistry, 9(1), 27-54. doi:10.1016/0045-2068(80)90031-0.

Cite as: https://hdl.handle.net/21.11116/0000-0008-40FC-4

Abstract

Syntheses by conventional procedures of the three analogs corresponding to the porcine secretin sequence crossed at position 6 by the N-terminal hexapeptide sequences of VIP, GIP, and glucagon are described, viz., Ala⁴,Val⁵-, Tyr¹,Ala²,Glu³-, and Gln³-secretin (VIP-SN, GIP-SN, and GLU-SN). The analog Phe¹,Phe²,Trp³,Lys⁴-secretin (SOMA-SN), designed on the basis of the surprising homology of the sequence portions 10–13 of somatostatin and 5–8 of secretin, was also prepared. Finally, the synthesis of N^α-3-(4-hydroxyphenyl)propionyl-β-alanyl-secretin (DATA-SN), a tracer suitable for secretin radioimmunoassay and as an N-terminus modified secretin analog, is reported. The analogs are compared, in terms of their biological and immunological properties in different assay systems, with pure synthetic secretin.