Carbonic anhydrase activity of isolated brush border and basal-lateral 
membranes of renal tubular cells

Wistrand, Per J.; Kinne, Rolf

doi:10.1007/BF00581684

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Carbonic anhydrase activity of isolated brush border and basal-lateral membranes of renal tubular cells

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Kinne, Rolf
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Wistrand, P. J., & Kinne, R. (1977). Carbonic anhydrase activity of isolated brush border and basal-lateral membranes of renal tubular cells. Pflügers Archiv: European Journal of Physiology, 370(2), 121-126. doi:10.1007/BF00581684.

Cite as: https://hdl.handle.net/21.11116/0000-0008-6E06-7

Abstract

Carbonic anhydrase activity was found and characterized in isolated homogeneous preparations of microvilli and basal infoldings of the rat renal tubular cells. This membrane-bound activity was about 3% of the total carbonic anhydrase activity of the renal cortex. Compared to the renal cytoplasmic soluble form, the membrane-bound enzymes had the same K_m for CO₂ and were equally resistant to inhibition by chloride. However, they were less inhibited by different sulfonamides. The implication of the existence of membrane-bound enzymes in the renal tubular cells is discussed.