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Book Chapter

Studies on the Molecular Mechanism of Anion Transport across the Red Blood Cell Membrane

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Passow,  Hermann
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Zaki,  Laila
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Passow, H., & Zaki, L. (1978). Studies on the Molecular Mechanism of Anion Transport across the Red Blood Cell Membrane. In A. K. Solomon, & M. L. Karnovsky (Eds.), Molecular Specialization and Symmetry in Membrane Function (pp. 229-250). Harvard, USA: Harvard University Press. doi:10.4159/harvard.9780674367227.c14.


Cite as: http://hdl.handle.net/21.11116/0000-0008-49CD-0
Abstract
The elucidation of the molecular events that take place when an anion crosses the red blood cell membrane requires: 1. The demonstration of the existence of a specific anion transport system and the delineation of that system. 2. The biochemical identification of the membrane constituents involved in the transport process. 3. The assignment of specific functions to the identified constituents. 4. The reconstitution of the transport system from the isolated constituents in artificial membrane systems. This chapter is concerned with points 2 and 3. Some comments on point 1 will serve as an introduction. Existence and Delineation: The existence of an anion transport system in the red cell is demonstrated fairly easily by comparing anion transport in liposomes made from red-cell lipids with transport in the intact cells. Although such liposomes are permeable to anions, their permeability is many orders of magnitude smaller than the permeability of the membrane of the intact red cell. This indicates the presence in the intact cell membrane of one or several constituents that facilitate anion penetration.