Sensitive protein alignments at tree-of-life scale using DIAMOND

Buchfink, Benjamin; Reuter, Klaus; Drost, Hajk-Georg

doi:10.1038/s41592-021-01101-x

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Sensitive protein alignments at tree-of-life scale using DIAMOND

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Reuter, Klaus
Computer Center Garching (RZG), Max Planck Institute for Plasma Physics, Max Planck Society;

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Citation

Buchfink, B., Reuter, K., & Drost, H.-G. (2021). Sensitive protein alignments at tree-of-life scale using DIAMOND. Nature methods, 18, 366-368. doi:10.1038/s41592-021-01101-x.

Cite as: https://hdl.handle.net/21.11116/0000-0008-49F4-3

Abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.