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Nanopatterned materials for receptor crosstalk in cell adhesion

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Wei,  Q.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Posa,  F.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Cavalcanti-Adam,  E. A.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Wei, Q., Posa, F., & Cavalcanti-Adam, E. A. (2021). Nanopatterned materials for receptor crosstalk in cell adhesion. Talk presented at Nanobiotechnology for Cell Interfaces. 733. WE-Heraeus-Seminar. Online. 2021-03-17 - 2021-03-18.


Cite as: http://hdl.handle.net/21.11116/0000-0008-4BD1-8
Abstract
The crosstalk between different receptor types at the interface with the extracellular environment is crucial for cell adhesion, migration and differentiation. Nanopatterned surfaces which combine adhesive ligands and growth factors allow to study how local changes in the extracellular environment regulate cell responses through specific receptor-ligand interactions. For adhesion to the extracellular matrix, integrin lateral clustering strongly influences cell adhesion dynamics and forces [1]. The nanoscale presentation of integrin ligands combined with growth factors, namely BMP-2 and BMP-6, modulates not only the specific interaction with different integrin types [3], but also the osteogenic differentiation of cells [4, 5]. Such nanopatterning approaches can be also applied to hydrogels of varying stiffness to elucidate the interdependency of mechanotransduction and differentiation signaling [6].