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Journal Article

Glucose makes Treg lose their temper

MPS-Authors
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Villa,  Matteo
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Pearce,  Erika L
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;
External Organizations;

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Citation

Villa, M., O'Sullivan, D., & Pearce, E. L. (2021). Glucose makes Treg lose their temper. Cancer Cell, 39, 460-462. doi:10.1016/j.ccell.2021.03.001.


Cite as: http://hdl.handle.net/21.11116/0000-0008-5146-E
Abstract
Competition for glucose regulates the balance between cancer and immune responses. New findings published in Nature show that regulatory T cells (Treg) shape their metabolism to avoid glucose competition, thus maintaining their stability and sustaining tumor progression. This research suggests hijacking the "eating habits" of Treg could improve cancer therapy.