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Luminal Sodium Phosphate Cotransport as the Site of Regulation for Tubular Phosphate Reabsorption: Studies with Isolated Membrane Vesicles

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Murer,  Heini
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Stoll,  Reinhard
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Evers,  Carla
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Kinne,  Rolf
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Murer, H., Stoll, R., Evers, C., Kinne, R., Bonjour, J.-P., & Fleisch, H. (1980). Luminal Sodium Phosphate Cotransport as the Site of Regulation for Tubular Phosphate Reabsorption: Studies with Isolated Membrane Vesicles. In Current Topics in Membranes and Transport (pp. 275-281). Academic Press Inc. doi:10.1016/S0070-2161(08)60287-7.


Cite as: http://hdl.handle.net/21.11116/0000-0008-53AE-7
Abstract
Publisher Summary: This chapter describes experiments in which alterations in proximal tubular inorganic phosphate (Pi) reabsorption were achieved in vivo by various means and sodium-dependent transport of Pi across the luminal membrane was analyzed in vitro with isolated membrane vesicles. Transport of Pi across cells consists of the following: (1) uphill influx across the brush border membrane via a sodium–Pi cotransport system driven by the gradients of sodium and Pi across the brush border membrane and (2) efflux of Pi at the contraluminal cell side driven by the electrochemical potential difference for Pi. The administration of parathyroid hormone slowed down the initial uptake phase and also reduced the intravesicular accumulation of Pi; however, this hormone did not provoke an alteration in the uptake of Pi in the absence of sodium. In the different situations tested earlier, a significant change was observed only in the sodium-dependent transport of Pi and not in the sodium-dependent transport of glucose. A close relationship exists between the estimate of the tubular capacity for Pi reabsorption of the whole kidney and the Pi uptake in the brush border vesicles measured under various conditions. Such a correlation strongly suggests that the translocation step across the brush border membrane is of primary importance in the regulation of the transport of Pi along the renal tubule.