Structural Changes of Spectrin in Solution Influenced by NaCl and CaCl2

Brauer, E.; Kupka, K.-D.; Rudloff, Victor

doi:10.1016/0302-4598(87)87022-8

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Structural Changes of Spectrin in Solution Influenced by NaCl and CaCl₂

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Rudloff, Victor
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Brauer, E., Kupka, K.-D., & Rudloff, V. (1978). Structural Changes of Spectrin in Solution Influenced by NaCl and CaCl₂. Bioelectrochemistry and Bioenergetics, 5(1), 223-231. doi:10.1016/0302-4598(87)87022-8.

Cite as: https://hdl.handle.net/21.11116/0000-0008-6086-4

Abstract

A molecular model was used to calculate the overall structure of spectrin in solutions of various salt contents. The electrostatic interaction is very weak since electrostatic forces stretch the molecule over a wide range. Counter-ions cause a decrease in the average radius of expansion. These results found by electrometric titration are in agreement with ultracentrifugal measurements.

UV-absorption and conductivity measurements indicate oligomerisation of spectrin beginning at a calcium concentration range below 1 mM.