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Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]i increase in rat pancreatic acinar cells

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Pröfrock,  André
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Piiper,  Albrecht
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Eckhardt,  Luise
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Schulz,  Irene
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Pröfrock, A., Piiper, A., Eckhardt, L., & Schulz, I. (1991). Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]i increase in rat pancreatic acinar cells. Biochemical and Biophysical Research Communications, 180(2), 900-906. doi:10.1016/S0006-291X(05)81150-7.


Cite as: https://hdl.handle.net/21.11116/0000-0008-67DF-A
Abstract
We have studied the effects of epidermal growth factor (EGF) on both cholecystokinin octapeptide (CCK-OP)-induced inositol-1,4,5 trisphosphate (IP) production and on cytosolic free calcium concentrations [Ca2+]i by fluorescence measurements in fura-2-loaded pancreatic acini. Our data show that EGF inhibits CCK-OP induced IP3 production by 40 ± 9 % and decreases CCK-OP induced rise in cytosolic Ca2+ by 41 ± 9 %. These data indicate that activation of EGF receptors leads to inhibition of CCK-OP induced stimulation of phospholipase C (PLC).