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Journal Article

Analysis of patchclamp recordings: model-free multiscale methods and software


Munk,  A.
Research Group of Statistical Inverse-Problems in Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Pein, F., Eltzner, B., & Munk, A. (2021). Analysis of patchclamp recordings: model-free multiscale methods and software. European Biophysics Journal, 50(2), 187-209. doi:10.1007/s00249-021-01506-8.

Cite as: https://hdl.handle.net/21.11116/0000-0008-7213-2
Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free multiscale idealization methodology JSMURF, JULES, and HILDE. We provide an operational manual how to use the accompanying software available as an R-package and as a graphical user interface. This includes selection of the right approach and tuning of parameters. We also discuss advantages and disadvantages of model-free approaches in comparison to hidden Markov model approaches and explain how they complement each other.