English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

MPS-Authors
/persons/resource/persons260636

Chen,  Fu-Der
Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;
Max Planck - University of Toronto Centre for Neural Science and Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

Valiante,  Taufik A.
External Organizations;
Max Planck - University of Toronto Centre for Neural Science and Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

External Resource
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

s41467-021-22741-9.pdf
(Publisher version), 8MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Moradi Chameh, H., Rich, S., Wang, L., Chen, F.-D., Zhang, L., Carlen, P. L., et al. (2021). Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences. Nature Communications, 12: 2497. doi:10.1038/s41467-021-22741-9.


Cite as: https://hdl.handle.net/21.11116/0000-0008-7262-9
Abstract
In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To characterize this potential distinctiveness, we use in vitro whole-cell recordings from cortical layers 2 and 3 (L2&3), layer 3c (L3c) and layer 5 (L5) of the human cortex. Across all layers we observe notable heterogeneity, indicating human cortical pyramidal neurons are an electrophysiologically diverse population. L5 pyramidal cells are the most excitable of these neurons and exhibit the most prominent sag current (abolished by blockade of the hyperpolarization activated cation current, Ih). While subthreshold resonance is more common in L3c and L5, we rarely observe this resonance at frequencies greater than 2 Hz. However, the frequency dependent gain of L5 neurons reveals they are most adept at tracking both delta and theta frequency inputs, a unique feature that may indirectly be important for the generation of cortical theta oscillations.