Magnetic resonance imaging-based changes in vascular morphology and cerebral 
perfusion in subacute ischemic stroke

Kufner, Anna; Khalil, Ahmed; Galinovic, Ivana; Kellner, Elias; Mekle, Ralf; Rackoll, Torsten; Boehm-Sturm, Philipp; Fiebach, Jochen B; Flöel, Agnes; Ebinger, Martin; Endres, Matthias; Nave, Alexander H

doi:10.1177/0271678X211010071

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke

MPS-Authors

/persons/resource/persons215473

Khalil, Ahmed
Center for Stroke Research, Charité University Medicine Berlin, Germany;
Berlin Institute of Health (BIH), Germany;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

Kufner_2021.pdf
(出版社版), 971KB

付随資料 (公開)

There is no public supplementary material available

引用

Kufner, A., Khalil, A., Galinovic, I., Kellner, E., Mekle, R., Rackoll, T., Boehm-Sturm, P., Fiebach, J. B., Flöel, A., Ebinger, M., Endres, M., & Nave, A. H. (2021). Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 41(10), 2617-2627. doi:10.1177/0271678X211010071.

引用: https://hdl.handle.net/21.11116/0000-0008-7B0D-1

要旨

MRI-based vessel size imaging (VSI) allows for in-vivo assessment of cerebral microvasculature and perfusion. This exploratory analysis of vessel size (VS) and density (Q; both assessed via VSI) in the subacute phase of ischemic stroke involved sixty-two patients from the BAPTISe cohort ('Biomarkers And Perfusion--Training-Induced changes after Stroke') nested within a randomized controlled trial (intervention: 4-week training vs. relaxation). Relative VS, Q, cerebral blood volume (rCBV) and -flow (rCBF) were calculated for: ischemic lesion, perilesional tissue, and region corresponding to ischemic lesion on the contralateral side (mirrored lesion). Linear mixed-models detected significantly increased rVS and decreased rQ within the ischemic lesion compared to the mirrored lesion (coefficient[standard error]: 0.2[0.08] p = 0.03 and -1.0[0.3] p = 0.02, respectively); lesion rCBF and rCBV were also significantly reduced. Mixed-models did not identify time-to-MRI, nor training as modifying factors in terms of rVS or rQ up to two months post-stroke. Larger lesion VS was associated with larger lesion volumes (β 34, 95%CI 6.2-62; p = 0.02) and higher baseline NIHSS (β 3.0, 95%CI 0.49-5.3;p = 0.02), but was not predictive of six-month outcome. In summary, VSI can assess the cerebral microvasculature and tissue perfusion in the subacute phases of ischemic stroke, and may carry relevant prognostic value in terms of lesion volume and stroke severity.