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Dysregulating ClpP: From Antibiotics to Anticancer?

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Citation

Dougan, D. A., Hantke, I., & Turgay, K. (2018). Dysregulating ClpP: From Antibiotics to Anticancer?.

Abstract

In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.