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Single-cell motion of magnetotactic bacteria in microfluidic confinement : interplay between surface interaction and magnetic torque

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Codutti,  Agnese
Damien Faivre, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;
Stefan Klumpp, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Charsooghi,  Mohammad
Damien Faivre, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Cerdá Doñate,  Elisa
Damien Faivre, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Taïeb,  Hubert M.
Amaia Cipitria, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Robinson,  Tom
Tom Robinson, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Faivre,  Damien
Damien Faivre, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121488

Klumpp,  Stefan
Stefan Klumpp, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Codutti, A., Charsooghi, M., Cerdá Doñate, E., Taïeb, H. M., Robinson, T., Faivre, D., et al. (2021). Single-cell motion of magnetotactic bacteria in microfluidic confinement: interplay between surface interaction and magnetic torque. bioRxiv, 2021.03.27.437322. doi:10.1101/2021.03.27.437322.


Cite as: http://hdl.handle.net/21.11116/0000-0008-84F6-D
Abstract
Swimming microorganisms often experience complex environments in their natural habitat. The same is true for microswimmers in envisioned biomedical applications. The simple aqueous conditions typically studied in the lab differ strongly from those found in these environments and often exclude the effects of small volume confinement or the influence that external fields have on their motion. In this work, we investigate magnetically steerable microswimmers, specifically magnetotactic bacteria, in strong spatial confinement and under the influence of an external magnetic field. We trap single cells in micrometer-sized microfluidic chambers and track and analyze their motion, which shows a variety of different trajectories, depending on the chamber size and the strength of the magnetic field. Combining these experimental observations with simulations using a variant of an active Brownian particle model, we explain the variety of trajectories by the interplay between the wall interactions and the magnetic torque. We also analyze the pronounced cell-to-cell heterogeneity, which makes single-cell tracking essential for an understanding of the motility patterns. In this way, our work establishes a basis for the analysis and prediction of microswimmer motility in more complex environments.