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Journal Article

Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe

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Parmar,  Asha
Singh Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany;

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Sharma,  Gargi
Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;

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Sharma,  Shivani
Singh Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany;

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Singh,  Kanwarpal
Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;
Singh Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society;
Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany;

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09399114.pdf
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Citation

Parmar, A., Sharma, G., Sharma, S., & Singh, K. (2021). Portable Optical Coherence Elastography System With Flexible and Phase Stable Common Path Optical Fiber Probe. IEEE Access, 9, 56041-56048. doi:10.1109/ACCESS.2021.3071793.


Cite as: http://hdl.handle.net/21.11116/0000-0008-7DE6-9
Abstract
Biomechanical properties drive the functioning of cells and tissue. Measurement of such properties in the clinic is quite challenging, however. Optical coherence elastography is an emerging technique in this field that can measure the biomechanical properties of the tissue. Unfortunately, such systems have been limited to benchtop configuration with limited clinical applications. A truly portable system with a flexible probe that could probe different sample sites with ease is still missing. In this work, we report a portable optical coherence elastography system based on a flexible common path optical fiber probe. The common path approach allows us to reduce the undesired phase noise in the system by an order of magnitude less than the standard non-common path systems. The flexible catheter makes it possible to probe different parts of the body with ease. Being portable, our system can be easily transported to and from the clinic. We tested the efficacy of the system by measuring the mechanical properties of the agar-based tissue phantoms. We also measured the mechanical properties (Young’s Modulus) of the human skin at different sites. The measured values for the agar phantom and the skin were found to be comparable with the previously reported studies. Ultra-high phase stability and flexibility of the probe along with the portability of the whole system makes an ideal combination for the faster clinical adoption of the optical coherence elastography technique.