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Journal Article

Calcium ion uptake induced by cholinergic and α-adrenergic stimulation in isolated cells of rat salivary glands

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Koelz,  Hans Rudolf
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Medizinische Klinik, Stadtspital Triemli, Birmensdorfer-Strasse 497, CH-8063, Zürich, Switzerland;

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Kondo,  S.
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
School of Medicine, Dept. of Dermatology, Yamagata University, Yamagata City, Japan;

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Blum,  A.L.
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;
Medizinische Klinik, Stadtspital Triemli, Birmensdorfer-Strasse 497, CH-8063, Zürich, Switzerland;

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Schulz,  Irene
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Koelz, H. R., Kondo, S., Blum, A., & Schulz, I. (1977). Calcium ion uptake induced by cholinergic and α-adrenergic stimulation in isolated cells of rat salivary glands. Pflügers Archiv: European Journal of Physiology, 370(1), 37-44. doi:10.1007/BF00707943.


Cite as: https://hdl.handle.net/21.11116/0000-000A-5438-9
Abstract
Adrenaline (10-5M) and carbamylcholine (10-4M) stimulate 45Ca2+ uptake into isolated cells of rat submandibular galnd and parotid glands. In the presence of the alpha-adrenoreceptor blocking agent phentolamine, adrenaline stimulation of 45Ca2+ uptake is abolished. The beta-adrenergic stimulant isoproterenol has no effect on 45Ca2+ uptake. Carbamylcholine induced 45Ca2+ uptake is inhibited by atropine. The Ca2+ ionophore A23187 stimulates 45Ca2+ uptake, whereas dibutyryl cyclic adenosine 3',5'-monophosphate and dibutyryl cyclic guanosine 3',5'-monophosphate have no effect on 45Ca2+ uptake. A graphical analysis of the 45Ca2+ uptake curves reveals at least two phases: a fast phase and a slow phase, both of which are stimulated by adrenaline and carbamylcholine. The 45Ca-exchangeable pool size is increased by adrenaline and carbamylcholine in both the fast and the slow phases. These results suggest that alpha-adrenergic and cholinergic agonists act by increasing the rate of Ca2+ transfer into the cells of the parotid and submandibular salivary glands most probably through an increase of the cell membrane permeability for Ca2+.