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Serum-induced inhibition of isotonic fluid absorption by the kidney proximal tubule. I. Mechanism of inhibition

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Sato,  Kenzo
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Ullrich,  Karl Julius
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Sato, K., & Ullrich, K. J. (1974). Serum-induced inhibition of isotonic fluid absorption by the kidney proximal tubule. I. Mechanism of inhibition. Biochimica et Biophysica Acta (BBA) - General Subjects, 343(3), 609-614. doi:10.1016/0304-4165(74)90279-7.


Cite as: https://hdl.handle.net/21.11116/0000-0008-9E65-5
Abstract
Isotonic reabsorption by the rat kidney proximal tubule was drastically inhibited after less than 2 min intraluminal perfusion with fresh sera from rat (both homologous and autologous), cat, rabbit and human, but not with sera from mouse and guinea pig. The inhibitory factor in serum in a heat (56° C for 30 min) and storage (4°C for 2–5 days) labile macromolecule (mol. wt 50 000) and requires Ca2+ for its effect. The cellular electrical potential difference of the proximal tubular cells was irreversively destroyed and intraluminally perfused trypan blue dye incorporated into the tubular cells after the intraluminal perfusion with serum for 2 min. These observations suggest that lysis of the proximal tubular cells is the mechanism for serum-induced inhibition of proximal tubular isotonic reabsorption.