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Improved prospective frequency correction for macromolecule-suppressed GABA editing with metabolite cycling at 3T

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Henning,  A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Chan, K., Hock, A., Edden, R., MacMillan, E., & Henning, A. (2021). Improved prospective frequency correction for macromolecule-suppressed GABA editing with metabolite cycling at 3T. Poster presented at 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).


Cite as: http://hdl.handle.net/21.11116/0000-0008-8649-F
Abstract
Macromolecule-suppressed GABA-editing with symmetrical suppression is often preferred over conventional GABA-editing due to its greater specificity. However, this pulse sequence is more sensitive to magnetic field instabilities than conventional GABA-editing. This leads to macromolecule contamination in the edited GABA signal. Here, we combine metabolite cycling with J-difference (MC-MEGA) editing to allow for prospective volume-localized frequency correction at each repetition time without the acquisition of additional water reference transients. We show here that prospective MC-MEGA reduces B0 field instability relative to intermittent prospective frequency correction with water suppressed (WS) MEGA and reduces macromolecule contamination and subtraction artifacts.