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The vessel size specificity and sensitivity of rapid CPMG sequences in functional BOLD imaging

MPS-Authors
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Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Heule,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Scheffler, K., Engelmann, J., & Heule, R. (2021). The vessel size specificity and sensitivity of rapid CPMG sequences in functional BOLD imaging. Poster presented at 2021 ISMRM & SMRT Annual Meeting & Exhibition (ISMRM 2021).


Cite as: http://hdl.handle.net/21.11116/0000-0008-87F3-D
Abstract
For reduced refocusing flip angles, the peak of the vessel size sensitivity curve is shifting towards larger radii with increasing echo time. The BOLD sensitivity is largely independent of the refocusing flip angle down to about 40°. CPMG or GRASE can be used with low refocusing flip angles without significant loss of sensitivity to BOLD and without the need for centric reordering. Signals acquired before or after the spin echo time point show contributions from larger vessels similar to gradient echo sequences. This effect is reduced for longer echo times.