S-type lectins occur also in invertebrates: high conservation of the 
carbohydrate recognition domain in the lectin genes from the marine sponge 
Geodia cydonium

Pfeifer, Karin; Haasemann, Martina; Gamulin, Vera; Bretting, Hagen; Fahrenholz, Falk; Müller, Werner E.G.

doi:10.1093/glycob/3.2.179

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S-type lectins occur also in invertebrates: high conservation of the carbohydrate recognition domain in the lectin genes from the marine sponge Geodia cydonium

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Fahrenholz, Falk
Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Pfeifer, K., Haasemann, M., Gamulin, V., Bretting, H., Fahrenholz, F., & Müller, W. E. (1993). S-type lectins occur also in invertebrates: high conservation of the carbohydrate recognition domain in the lectin genes from the marine sponge Geodia cydonium. Glycobiology, 3(2), 179-184. doi:10.1093/glycob/3.2.179.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A544-1

Abstract

The marine sponge Geodia cydonium contains several lectins. The main component, called lectin-1, is composed of three to four identical subunits. The subunits of the lectins were cloned from a cDNA library; two clones were obtained. From the deduced aa sequence of one clone, LECT-1, a mol. wt of 15,313 Da is calculated; this value is in good agreement with mass spectrometric analysis of 15,453 ± 25 Da. The sequence of another clone, LECT-2, was analysed and the aa sequence was deduced (15,433 Da). The two subunits have a framework sequence of 38 conserved aa which are characteristic for the carbohydrate-binding site of vertebrate S-type lectins. Clustering of lectin sequences of various species following their pairwise comparison establishes a dendrogram, which reveals that the sponge lectin could be considered as the ancestor for vertebrate S-type lectins.