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Journal Article

Cecal Enlargement Combined with Sodium Transport Stimulation in Rats Fed Polyethylene Glycol

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Loeschke,  Klaus
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Uhlich,  Eike
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Halbach,  Regine
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Loeschke, K., Uhlich, E., & Halbach, R. (1973). Cecal Enlargement Combined with Sodium Transport Stimulation in Rats Fed Polyethylene Glycol. Proceedings of the Society for Experimental Biology and Medicine, 142(1), 96-102. doi:10.3181/00379727-142-36966.


Cite as: https://hdl.handle.net/21.11116/0000-0008-A519-2
Abstract
The organ enlargement and stimulation of solute–coupled water transport observed in the cecum of germfree rats can also be produced in conventional rats by adding polyethylene glycol 4000 to their drinking water. In these rats, the electrical potential difference across the cecal wall is increased during solute–coupled water flow. The structural and functional changes induced by polyethylene glycol are reversible and do not extend to the rest of the small intestine and the distal ileum.