A metabolic switch regulates the transition between growth and diapause in C. 
elegans.

Penkov, Sider; Raghuraman, Bharath Kumar; Erkut, Cihan; Oertel, Jana; Galli, Roberta; Ackerman, Eduardo Jacobo Miranda; Vorkel, Daniela; Verbavatz, Jean-Marc; Koch, Edmund; Fahmy, Karim; Shevchenko, Andrej; Kurzchalia, Teymuras V.

doi:10.1186/s12915-020-0760-3

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A metabolic switch regulates the transition between growth and diapause in C. elegans.

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Penkov, Sider
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Raghuraman, Bharath Kumar
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Erkut, Cihan
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Vorkel, Daniela
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Verbavatz, Jean-Marc
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Shevchenko, Andrej
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219360

Kurzchalia, Teymuras V.
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Penkov, S., Raghuraman, B. K., Erkut, C., Oertel, J., Galli, R., Ackerman, E. J. M., et al. (2020). A metabolic switch regulates the transition between growth and diapause in C. elegans. BMC biology, 18(1): 31. doi:10.1186/s12915-020-0760-3.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A246-2

Abstract

Metabolic activity alternates between high and low states during different stages of an organism's life cycle. During the transition from growth to quiescence, a major metabolic shift often occurs from oxidative phosphorylation to glycolysis and gluconeogenesis. We use the entry of Caenorhabditis elegans into the dauer larval stage, a developmentally arrested stage formed in response to harsh environmental conditions, as a model to study the global metabolic changes and underlying molecular mechanisms associated with growth to quiescence transition.