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Basal Progenitor Morphology and Neocortex Evolution.

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Kalebic,  Nereo
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Huttner,  Wieland
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Kalebic, N., & Huttner, W. (2020). Basal Progenitor Morphology and Neocortex Evolution. Trends in neurosciences, 43(11), 843-853. doi:10.1016/j.tins.2020.07.009.


Cite as: https://hdl.handle.net/21.11116/0000-0008-A26C-8
Abstract
The evolutionary expansion of the mammalian neocortex is widely considered to be a basis of increased cognitive abilities. This expansion is a consequence of the enhanced production of neurons during the fetal/embryonic development of the neocortex, which in turn reflects an increased proliferative capacity of neural progenitor cells; in particular basal progenitors (BPs). The remarkable heterogeneity of BP subtypes across mammals, notably their various morphotypes and molecular fingerprints, which has recently been revealed, corroborates the importance of BPs for neocortical expansion. Here, we argue that the morphology of BPs is a key cell biological basis for maintaining their high proliferative capacity and therefore plays crucial roles in the evolutionary expansion of the neocortex.