Nutrients men-TOR β-Cells to Adulthood.

Katsumoto, Keiichi; Grapin-Botton, Anne

doi:10.1016/j.devcel.2020.06.028

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Nutrients men-TOR β-Cells to Adulthood.

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Katsumoto, Keiichi
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Grapin-Botton, Anne
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Katsumoto, K., & Grapin-Botton, A. (2020). Nutrients men-TOR β-Cells to Adulthood. Developmental cell, 54(2), 140-141. doi:10.1016/j.devcel.2020.06.028.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A308-7

Abstract

A major trigger of adult β-cell insulin secretion is glucose. In a recent issue of Cell Metabolism, Helman and colleagues show that in fetuses insulin secretion depends on the activation of mTOR by amino acids and that reducing amino acids promotes maturation of β-cells derived from pluripotent stem cells.