Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Regeneration of the pancreas: proliferation and cellular conversion of surviving cells.


Grapin-Botton,  Anne
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Sever, D., & Grapin-Botton, A. (2020). Regeneration of the pancreas: proliferation and cellular conversion of surviving cells. Current opinion in genetics & development, 64, 84-93. doi:10.1016/j.gde.2020.06.005.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A334-5
The most common pancreas-related disorders are diabetes, pancreatitis and different types of pancreatic cancers. Diabetes is a chronic condition which results from insufficient functional β-cell mass, either as a result of an autoimmune destruction of insulin producing β-cells, or as their death or de-differentiation following years of hyperactivity to compensate for insulin resistance. Chronic pancreatitis leads to cell death and can develop into diabetes or pancreatic cancer. To stimulate regeneration in such pathologies, it is of high importance to evaluate the endogenous regeneration capacity of the pancreas, to understand the conditions needed to trigger it, and to investigate the cellular and molecular regenerative responses. This short review focuses on observations made in the last 2 years on the mechanisms enhancing pancreatic cell proliferation, notably new combinations of pharmacological agents, as well as those triggering cellular conversion.