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Journal Article

Rising from the ashes: cellular senescence in regeneration.


Yun,  Maximina H
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Walters, H. E., & Yun, M. H. (2020). Rising from the ashes: cellular senescence in regeneration. Current opinion in genetics & development, 64, 94-100. doi:10.1016/j.gde.2020.06.002.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A340-7
Cellular senescence has recently become causally implicated in pathological ageing. Hence, a great deal of research is currently dedicated towards developing senolytic agents to selectively kill senescent cells. However, senescence also plays important roles in a range of physiological processes including during organismal development, providing a barrier to tumorigenesis and in limiting fibrosis. Recent evidence also suggests a role for senescence in coordinating tissue remodelling and in the regeneration of complex structures. Through its non-cell-autonomous effects, a transient induction of senescence may create a permissive environment for remodelling or regeneration through promoting local proliferation, cell plasticity, tissue patterning, balancing growth, or indirectly through finely tuned interactions with infiltrating immune mediators. A careful analysis of the beneficial roles of cellular senescence may provide insights into important physiological processes as well as informing strategies to counteract its detrimental consequences in ageing and disease.