The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein 
that controls insulin secretory granule biogenesis.

Carrat, Gaelle R; Haythorne, Elizabeth; Tomas, Alejandra; Haataja, Leena; Müller, Andreas; Arvan, Peter; Piunti, Alexandra; Cheng, Kaiying; Huang, Mutian; Pullen, Timothy J; Georgiadou, Eleni; Stylianides, Theodoros; Amirruddin, Nur Shabrina; Salem, Victoria; Distaso, Walter; Cakebread, Andrew; Heesom, Kate J; Lewis, Philip A; Hodson, David J; Briant, Linford J; Fung, Annie C H; Sessions, Richard B; Alpy, Fabien; Kong, Alice P S; Benke, Peter I; Torta, Federico; Teo, Adrian Kee Keong; Leclerc, Isabelle; Solimena, Michele; Wigley, Dale B; Rutter, Guy A

doi:10.1016/j.molmet.2020.101015

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The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

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Solimena, Michele
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Müller, A., Arvan, P., et al. (2020). The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Molecular metabolism, 40: 101015. doi:10.1016/j.molmet.2020.101015.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A36E-5

Abstract

Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the identity of the transported lipids and thus the pathways through which STARD10 regulates β-cell function are not understood. The aim of this study was to identify the lipids transported and affected by STARD10 in the β-cell and the role of the protein in controlling proinsulin processing and insulin granule biogenesis and maturation.