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Journal Article

Molecular networks of the FOXP2 transcription factor in the brain

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Den Hoed,  Joery
International Max Planck Research School for Language Sciences, MPI for Psycholinguistics, Max Planck Society;
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

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Devaraju,  Karthikeyan
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;

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Fisher,  Simon E.
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;

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Citation

Den Hoed, J., Devaraju, K., & Fisher, S. E. (2021). Molecular networks of the FOXP2 transcription factor in the brain. EMBO Reports, 22(8): e52803. doi:10.15252/embr.202152803.


Cite as: https://hdl.handle.net/21.11116/0000-0008-A453-1
Abstract
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to two decades of empirical studies focused on uncovering its roles in the brain using a range of in vitro and in vivo methods. Here, we discuss what we have learned about the regulation of FOXP2, its downstream effectors, and its modes of action as a transcription factor in brain development and function, providing an integrated overview of what is currently known about the critical molecular networks.