Cytomegalovirus distribution and evolution in hominines

Murthy, Sripriya; O’Brien, Kathryn; Agbor, Anthony; Angedakin, Samuel; Arandjelovic, Milica; Ayimisin, Ayuk Emmanuel; Bailey, Emma; Bergl, Richard A; Brazzola, Gregory; Dieguez, Paula; Eno-Nku, Manasseh; Eshuis, Henk; Fruth, Barbara; Gillespie, Thomas R; Yuh, Yisa Ginath; Gray, Maryke; Herbinger, Ilka; Jones, Sorrel; Kehoe, Laura; Kühl, Hjalmar S.; Kujirakwinja, Deo; Lee, Kevin; Madinda, Nadege Freda; Mitamba, Guillain; Muhindo, Emmanuel; Nishuli, Radar; Ormsby, Lucy Jayne; Petrzelkova, Klara J; Plumptre, Andrew J; Robbins, Martha M.; Sommer, Volker; Ter Heegde, Martijn; Todd, Angelique; Tokunda, Raymond; Wessling, Erin G.; Jarvis, Michael A; Leendertz, Fabian H; Ehlers, Bernhard; Calvignac-Spencer, Sébastien

doi:10.1093/ve/vez015

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Cytomegalovirus distribution and evolution in hominines

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Angedakin, Samuel
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Arandjelovic, Milica
Great Ape Evolutionary Ecology and Conservation, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Ayimisin, Ayuk Emmanuel
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Bailey, Emma
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Brazzola, Gregory
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Dieguez, Paula
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Eshuis, Henk
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Yuh, Yisa Ginath
Great Ape Evolutionary Ecology and Conservation, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons207405

Jones, Sorrel
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Kühl, Hjalmar S.
Great Ape Evolutionary Ecology and Conservation, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons200019

Lee, Kevin
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Madinda, Nadege Freda
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Ormsby, Lucy Jayne
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Robbins, Martha M.
Gorillas, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Wessling, Erin G.
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Citation

Murthy, S., O’Brien, K., Agbor, A., Angedakin, S., Arandjelovic, M., Ayimisin, A. E., et al. (2019). Cytomegalovirus distribution and evolution in hominines. Virus Evolution, 5(2): vez015. doi:10.1093/ve/vez015.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A961-C

Abstract

Herpesviruses are thought to have evolved in very close association with their hosts. This is notably the case for cytomegaloviruses (CMVs; genus Cytomegalovirus) infecting primates, which exhibit a strong signal of co-divergence with their hosts. Some herpesviruses are however known to have crossed species barriers. Based on a limited sampling of CMV diversity in the hominine (African great ape and human) lineage, we hypothesized that chimpanzees and gorillas might have mutually exchanged CMVs in the past. Here, we performed a comprehensive molecular screening of all 9 African great ape species/subspecies, using 675 fecal samples collected from wild animals. We identified CMVs in eight species/subspecies, notably generating the first CMV sequences from bonobos. We used this extended dataset to test competing hypotheses with various degrees of co-divergence/number of host switches while simultaneously estimating the dates of these events in a Bayesian framework. The model best supported by the data involved the transmission of a gorilla CMV to the panine (chimpanzee and bonobo) lineage and the transmission of a panine CMV to the gorilla lineage prior to the divergence of chimpanzees and bonobos, more than 800,000 years ago. Panine CMVs then co-diverged with their hosts. These results add to a growing body of evidence suggesting that viruses with a double-stranded DNA genome (including other herpesviruses, adenoviruses, and papillomaviruses) often jumped between hominine lineages over the last few million years.