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Conference Paper

Photoreactive Agonists and Antagonists of Neuroypophysial Hormones for Receptor Studies

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Fahrenholz,  Falk
Department of Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Kojro,  Elzbieta
Department of Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Boer,  Rainer
Department of Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Fahrenholz, F., Kojro, E., & Boer, R. (1987). Photoreactive Agonists and Antagonists of Neuroypophysial Hormones for Receptor Studies. In D. Theodoropoulos (Ed.), European Peptide Symposium: Peptides (pp. 469-472). Berlin: De Gruyter. doi:10.1515/9783110864243-109.


Cite as: https://hdl.handle.net/21.11116/0000-0008-AD49-4
Abstract
Photoreactive analogues of vasopressin have been synthesized and used to identify vasopressin receptor proteins in plasma membranes from different target organs (1,2):V1 vasopressin receptors (coupled to Ca2+ -mobilization) in rat liver and V2 vasopressin receptors (coupled to adenylate cyclase) in kidney medulla from different mammalian species. The question as to whether vasopressin agonists and antagonists interact with the same subunits of vasopressin receptor proteins remains open. Furthermore, at present we have no information which amino acid residues in the vasopressin molecule are close to the hormone binding site in the hormone-receptor complex. In this report we describe the synthesis of potent photoreactive vasopressin agonists and antagonists an their employment in receptor studies to answer these questions.