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Journal Article

The permeability of the human red blood cell to sulfate ions

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Lepke,  Sigrid
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;
II. Physiologisches Institut der Universität des Saarlandes, 665, Homburg (Saar), Germany;

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Passow,  Hermann
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;
II. Physiologisches Institut der Universität des Saarlandes, 665, Homburg (Saar), Germany;

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Citation

Lepke, S., & Passow, H. (1971). The permeability of the human red blood cell to sulfate ions. Journal of Membrane Biology, 6(2), 158-182. doi:10.1007/BF01873461.


Cite as: https://hdl.handle.net/21.11116/0000-0008-AF94-C
Abstract
Sulfate permeability was measured at Donnan equilibrium as a function of three variables, the sulfate, chloride, and hydrogen ion concentration in the medium. The data were used for a quantitative evaluation of a number of typical predictions of a fixed charge model of the ion permeable regions of the red blood cell membrane. It could be shown that more than 1,000-fold variations of sulfate flux, JSO4, could be represented as a function of a single variable SO2−4m, the sulfate concentration in the membrane. SO2−4m was calculated from the measured values of all three variables by means of a previously published equation (Passow,Progress in Biophysics and Molecular Biology, vol. 19, pt. II, pp. 425–467, 1969). In this equation, two constants can be arbitrarily chosen: Ā, the sum of the charged and uncharged forms of dissociable fixed charges, andK, the dissociation constant of the fixed charges. For the present calculations, the previously obtained values Ā=2.5 and K=1·10−9 were used.