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Journal Article

Neutrophils self-limit swarming to contain bacterial growth in vivo

MPS-Authors

Kienle,  Korbinian
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Glaser,  Katharina M
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Mihlan,  Michael
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Epple,  Maximilian W
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Lämmermann,  Tim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Kienle, K., Glaser, K. M., Eickhoff, S., Mihlan, M., Knöpper, K., Reátegui, E., et al. (2021). Neutrophils self-limit swarming to contain bacterial growth in vivo. Science, 372: eabe7729. doi:10.1126/science.abe7729.


Cite as: http://hdl.handle.net/21.11116/0000-0008-C5D3-B
Abstract
Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism to self-limit swarming and avoid uncontrolled aggregation during inflammation. G protein–coupled receptor (GPCR) desensitization acts as a negative feedback control to stop migration of neutrophils when they sense high concentrations of self-secreted attractants that initially amplify swarming. Interference with this process allows neutrophils to scan larger tissue areas for microbes. Unexpectedly, this does not benefit bacterial clearance as containment of proliferating bacteria by neutrophil clusters becomes impeded. Our data reveal how autosignaling stops self-organized swarming behavior and how the finely tuned balance of neutrophil chemotaxis and arrest counteracts bacterial escape.