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Conference Paper

Natural Peptide Lactones As Ion Carriers In Membranes

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Oberbäumer,  Ilse
Molecular Biophysics Group, Max Planck Institute of Biophysics, Max Planck Society;

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Feigl,  Peter
Molecular Biophysics Group, Max Planck Institute of Biophysics, Max Planck Society;

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Ruf,  Horst
Molecular Biophysics Group, Max Planck Institute of Biophysics, Max Planck Society;

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Grell,  Ernst
Molecular Biophysics Group, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Oberbäumer, I., Feigl, P., Ruf, H., & Grell, E. (1981). Natural Peptide Lactones As Ion Carriers In Membranes. In W. Voelter (Ed.), Structure and Activity of Natural Peptides (pp. 349-362). Berlin, New York: Walter de Gruyter & Co.,. doi:10.1515/9783110861631-037.


Cite as: https://hdl.handle.net/21.11116/0000-0008-CD71-2
Abstract
The streptogramins are a well-known family of antibiotics that are produced by several streptomycetes. According to their different structures these antibiotics have been classified into the two groups A and B. All members of group A are macrocyclic lactones while those of group B are peptide lac-tones containing six to seven amino acid residues in the ring. The structures of the three main components of group B are shown in Fig. 1.
It has been generally accepted that the streptogramins of both groups interact with the bacterial 50 S ribosomal subunit and block protein biosynthesis. The A components interfere with the ribosomal peptidyl transferase, whereas the effect of the B components appears to be rather indirect.