3D 31P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative 
analysis of metabolic images

Ruhm, L; Dorst, J; Avdievitch, N; Wright, AM; Henning, A

doi:10.1002/mrm.28891

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

3D 31P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images

MPS-Authors

/persons/resource/persons215122

Ruhm, L
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons215104

Dorst, J
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133464

Avdievitch, N
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons215127

Wright, AM
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84402

Henning, A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://onlinelibrary.wiley.com/doi/epdf/10.1002/mrm.28891
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Ruhm, L., Dorst, J., Avdievitch, N., Wright, A., & Henning, A. (2021). 3D 31P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images. Magnetic Resonance in Medicine, 86(5), 2368-2383. doi:10.1002/mrm.28891.

Cite as: https://hdl.handle.net/21.11116/0000-0008-D46E-E

Abstract

Purpose: To present 31 P whole brain MRSI with a high spatial resolution to probe quantitative tissue analysis of 31 P MRSI at an ultrahigh field strength of 9.4 Tesla.

Methods: The study protocol included a 31 P MRSI measurement with an effective resolution of 2.47 mL. For SNR optimization, the nuclear Overhauser enhancement at 9.4 Tesla was investigated. A sensitivity correction was achieved by applying a low rank approximation of the γ-adenosine triphosphate signal. Group analysis and regression on individual volunteers were performed to investigate quantitative concentration differences between different tissue types.

Results: Differences in gray and white matter tissue 31 P concentrations could be investigated for 12 different 31 P resonances. In addition, the first highly resolved quantitative MRSI images measured at B0 = 9.4 Tesla of 31 P detectable metabolites with high SNR could be presented.

Conclusion: With an ultrahigh field strength B0 = 9.4 Tesla, 31 P MRSI moves further toward quantitative metabolic imaging, and subtle differences in concentrations between different tissue types can be detected.