Mechanisms of sarcoplasmic reticulum functions and consequences for muscle 
activity

Hasselbach, Wilhelm

doi:10.1007/978-1-4613-2053-1_15

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Mechanisms of sarcoplasmic reticulum functions and consequences for muscle activity

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Hasselbach, Wilhelm
Department of Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Hasselbach, W. (1987). Mechanisms of sarcoplasmic reticulum functions and consequences for muscle activity. In Heart Function and Metabolism: Proceedings of the Symposium held at the Eighth Annual Meeting of the American Section of the International Society for Heart Research, July 8–11, 1986, Winnipeg, Canada (pp. 243-253). Boston, MA: Springer.

Cite as: https://hdl.handle.net/21.11116/0000-0008-D90A-9

Abstract

The calcium concept of excitation-contraction coupling evolved from four basic findings:

1) The contractile machinery of all kinds of muscles contains calcium sensitive target proteins with similar calcium affinity (1–3).

2) During muscle contraction, the sarcoplasmic calcium level rises transiently from 0.1 µM to 10 µM (4–6).

3) Active calcium pumps guarantee a low resting calcium level, and a fast removal of calcium from the contractile proteins for relaxation (7–9), and

4) specific calcium storing and releasing structures supply the contractile machinery with calcium (10–12).