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Journal Article

Activation and inhibition of the calcium gate of sarcoplasmic reticulum by high-affinity ryanodine binding

MPS-Authors
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Hasselbach,  Wilhelm
Department of Physiology, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons94365

Migala,  Andrea
Department of Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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https://febs.onlinelibrary.wiley.com/doi/epdf/10.1016/0014-5793%2887%2980364-2
(Any fulltext)

https://doi.org/10.1016/0014-5793(87)80364-2
(Any fulltext)

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Citation

Hasselbach, W., & Migala, A. (1987). Activation and inhibition of the calcium gate of sarcoplasmic reticulum by high-affinity ryanodine binding. FEBS Letters, 221(1), 119-123. doi:10.1016/0014-5793(87)80364-2.


Cite as: https://hdl.handle.net/21.11116/0000-0008-D93E-F
Abstract
The occupancy of high-affinity ryanodine-binding sites of isolated heavy sarcoplasmic reticulum vesicles occurring in concentrated salt solutions affects ATP-dependent calcium accumulation and caffeine-induced calcium release. The initial suppression of calcium uptake is followed by a marked uptake activation resulting in a reduction of the final calcium level in the medium. Simultaneously, caffeine-induced calcium release is blocked. The dependence of inhibition of calcium uptake and caffeine-induced calcium release observed in assay media containing physiological concentrations of magnesium and ATP on the concentration of ryanodine corresponds to the drug's effectiveness in living muscles.